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Article

Highly pleiotropic variants of human traits are enriched in genomic regions with strong background selection

2021-03-24

Abstract excerpt

<title>Abstract</title> <p>Recent studies have shown the ubiquity of pleiotropy for variants affecting human complex traits. These studies also show that rare variants tend to be less pleiotropic than common ones, suggesting that purifying natural selection acts against highly pleiotropic variants of large effect. Here we investigate the mean frequency, effect size and recombination rate associated with pleiotrop...

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Literature Corpus work
a5c5f796-e300-5371-9730-6acbd5ffbe0e
DOI
10.21203/rs.3.rs-345603/v1
Open publication

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Highly pleiotropic variants of human traits are enriched in genomic regions with strong background selectionDOI 10.21203/rs.3.rs-345603/v1
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