Article
Cellular and molecular basis of PfCoronin function in artemisinin resistance in Plasmodium falciparum.
Nature communications - 7 May 2026
Ullah Imran, Farringer Madeline A, Khushu Malhar, Burkhard Anna Y, Hathaway Erica, Willett Bailey C, Shin Sara H, Sharma Aabha I, Mallick River, Istvan Eva S, Martin Morgan C, Harrigan Oliver, Shao Kairon L, Dvorin Jeffrey D, Hartl Daniel L, Volkman Sarah K, Bopp Selina, Absalon Sabrina, Wirth Dyann F
Abstract excerpt
Artemisinin combination therapies are central to malaria control, but their efficacy is threatened by the emergence of resistant Plasmodium falciparum strains. While the role of Pfkelch13 mutations is well established, mutations in Pfcoronin have also been implicated in treatment failure, revealing layers of resistance complexity. Here, we define the cellular mechanism of Pfcoronin‑mediated artemisinin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.