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Article

Exploratory study of DEFB1 genetic variants and human β-defensin-1 expression in monosodium urate crystal-induced arthritis: insights into innate immune regulation.

Molecular biology reports - 7 May 2026

Fernández-Torres Javier, Martínez-Flores Karina, López-Macay Ambar, Zamudio-Cuevas Yessica

Abstract excerpt

BACKGROUND: Gout is an inflammatory arthritis triggered by the deposition of monosodium urate crystals and characterized by activation of innate immune pathways. Human β-defensin-1 (hBD-1), encoded by the DEFB1 gene, is an antimicrobial peptide with immunomodulatory functions. However, its role in gout-related inflammation remains unclear. This study aimed to investigate the relationship between DEFB1 variants...

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Identifiers

PMID: 42095990
DOI: 10.1007/s11033-026-11919-3

Genes

DEFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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