Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of upstream ORF translation is not a widespread mechanism of translational stimulation by yeast helicase Ded1.

Nucleic acids research - 5 May 2026

Kumar Rakesh, May Gemma, Sen Neelam Dabas, McManus C Joel, Hinnebusch Alan G

Abstract excerpt

Ded1 is an essential DEAD-box helicase in yeast that broadly stimulates translation initiation and is critical for messenger RNAs (mRNAs) with structured 5' untranslated regions (UTRs). We have evaluated the proposal that Ded1 stimulates translation primarily by preventing initiation at upstream open-reading-frames (uORFs) associated with stable secondary structures. By Ribo-seq analysis under experimental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to DEAD-box RNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Fungal

Share to Open Reading Frames

Share to Peptide Chain Initiation, Translational

Share to Protein Biosynthesis

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42087789
DOI: 10.1093/nar/gkag427
PMCID: PMC13144874

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of upstream ORF translation is not a widespread mechanism of translational stimulation by yeast helicase Ded1.PMID 42087789Read ↗

Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A.Semantic proximity Read ↗

40S ribosomal subunits scan mRNA for the start codon by one-dimensional diffusion.Semantic proximity Read ↗

uORFdb--a comprehensive literature database on eukaryotic uORF biology.Semantic proximity Read ↗

Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiationSemantic proximity Read ↗

Some like it translated: small ORFs in the 5′UTRSemantic proximity Read ↗

5′-UTR G-Quadruplex-Mediated Translation Regulation in Eukaryotes: Current Understanding and Methodological ChallengesSemantic proximity Read ↗

Translational buffering by ribosome stalling in upstream open reading framesSemantic proximity Read ↗

Leaky scanning translates a conserved ORF in the 3′UTR of RPL36A and regulates the expression of ribosomal protein L36a.Semantic proximity Read ↗

<i>uORF-Tools</i> – Workflow for the determination of translation-regulatory upstream open reading framesSemantic proximity Read ↗

Sequence-intrinsic barriers define a class of translation-restricted uORFs in the human genomeSemantic proximity Read ↗

An <i>in vitro</i> assay of MCTS1-DENR-dependent re-initiation and ribosome profiling uncover the activity of MCTS2 and distinct function of eIF2DSemantic proximity Read ↗

DDX3 depletion represses translation of mRNAs with complex 5' UTRs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.