Article
The effects of the PHF6 gene mutation on myeloid neoplasms. A single-center cohort underpinned by a systematic review of literature.
Annals of hematology - 4 Feb 2026
Suárez Edwin U, Atencia Carlos J, Torres-Saavedra Fabio A, Conejero Nazareth, Salgado Rocío, Atance-Pararisas Mireia, Perlado Sara, Soto Carlos, Alonso-Domínguez Juan M, Arquero-Portero Teresa, Mata Raquel, Jiménez Elena, López-Lorenzo J L, Arriero Álvaro V, Serrano-López Juana, Rodríguez-Pinilla Socorro M, Llamas Pilar
Abstract excerpt
The mutation of the plant homeodomain finger protein 6 gene (PHF6MUT) in patients with myeloid neoplasms (MNs) is rare and appears to play a role in prognosis, though this is still under debate. We conducted a retrospective analysis of a cohort of 313 patients diagnosed with MNs. We also performed a systematic review (SR) of the literature to evaluate the prognostic role of PHF6 gene status in MNs. We identified...
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