Genetic determinants of risk and progression in multiple sclerosis.

doi:10.1016/j.cca.2015.01.034

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Article

Genetic determinants of risk and progression in multiple sclerosis.

Clinica chimica acta; international journal of clinical chemistry - 20 Sept 2015

Didonna Alessandro, Oksenberg Jorge R

Abstract excerpt

Multiple sclerosis (MS) is an autoimmune disease that represents a primary cause of neurological disability in the young adult population. Converging evidence supports the importance of genetic determinants for MS etiology. However, with the exception of the major histocompatibility complex, their nature has been elusive for more than 20 years. In the last decade, the advent of large genome-wide association...

Topics

Disease Progression
Epigenesis, Genetic
Genetic Predisposition to Disease
Genetic Variation
Humans
Major Histocompatibility Complex
Multiple Sclerosis

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Identifiers

PMID: 25661088
DOI: 10.1016/j.cca.2015.01.034
PMCID: PMC4524789

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