Article
Decoding multiple sclerosis: an update on genomics and future directions.
Expert review of neurotherapeutics - 1 Dec 2013
Oksenberg Jorge R
Abstract excerpt
A wealth of data confirms that genetic variation is an important determinant of multiple sclerosis (MS) risk. Population, family and molecular studies provide strong empirical support for a polygenic model of inheritance, driven primarily by allelic variants relatively common in the general population. The major histocompatibility complex (MHC) in chromosome 6p21.3 represents by far the strongest MS...
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