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Article

H3F3B p.K27I-mutant diffuse midline glioma is a distinct subtype of H3K27-altered diffuse midline glioma.

Acta neuropathologica communications - 23 Aug 2025

Cheng Lei, Zhou Min, Luo Tao, Dong Rongfang, Chen Ni, Cai Xinyong, Wang Xingwen, Wu Hao, Chen Zan, Wang Zuowei, Qi Xueling, Lu Dehong, Teng Lianghong, Jian Fengzeng, Wang Leiming

Abstract excerpt

H3K27-altered diffuse midline glioma (DMG) is a fatal disease, including four subtypes H3.3-mutant, H3.1/H3.2-mutant, H3-wildtype with EZHIP overexpression, and EGFR-mutant. H3F3B, another gene encoding histone H3.3 in addition to H3F3A, was ever reported to be mutated in DMGs. However, the clinical and molecular characteristics of H3F3B-mutant DMGs is yet understood. The clinical and radiological information of...

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Identifiers

PMID: 40849656
DOI: 10.1186/s40478-025-02101-0
PMCID: PMC12374277

Genes

EGFR
EZHIP
NF1
PPM1D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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