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Article

Sequence-encoded determinants of regional mutational plasticity: comparative analysis of PE_PGRS genes in Mycobacterium tuberculosis and other bacteria.

Scientific reports - 2 May 2026

Slizen Veranika, Hurevich Henadz

Abstract excerpt

The PE_PGRS gene family in Mycobacterium tuberculosis exhibits extensive sequence variability across genotypes, which is consistent with antigenic divergence. Here we investigate how Mtb-despite lacking horizontal gene transfer-balances genomic stability with adaptive plasticity. Comparative analysis of 88 bacterial genomes reveals that PE_PGRS genes exhibit features facilitating mutability, including a...

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Identifiers

PMID: 42069913
DOI: 10.1038/s41598-026-47170-w
PMCID: PMC13328622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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