Article
Evolution of smooth tubercle Bacilli PE and PE_PGRS genes: evidence for a prominent role of recombination and imprint of positive selection.
PloS one - 1 Jan 2013
Namouchi Amine, Karboul Anis, Fabre Michel, Gutierrez Maria Cristina, Mardassi Helmi
Abstract excerpt
BACKGROUND: PE and PE_PGRS are two mycobateria-restricted multigene families encoding membrane associated and secreted proteins that have expanded mainly in the pathogenic species, notably the Mycobacterium tuberculosis complex (MTBC). Several lines of evidence attribute to PE and PE_PGRS genes critical roles in mycobacterial pathogenicity. To get more insight into the nature of these genes, we sought to address...
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