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Article

Homoplastic single nucleotide polymorphisms contributed to phenotypic diversity in Mycobacterium tuberculosis.

Scientific reports - 15 May 2020

Tantivitayakul Pornpen, Ruangchai Wuthiwat, Juthayothin Tada, Smittipat Nat, Disratthakit Areeya, Mahasirimongkol Surakameth, Viratyosin Wasna, Tokunaga Katsushi, Palittapongarnpim Prasit

Abstract excerpt

Homoplastic mutations are mutations independently occurring in different clades of an organism. The homoplastic changes may be a result of convergence evolution due to selective pressures. Reports on the analysis of homoplastic mutations in Mycobacterium tuberculosis have been limited. Here we characterized the distribution of homoplastic single nucleotide polymorphisms (SNPs) among genomes of 1,170 clinical M....

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Identifiers

PMID: 32415151
DOI: 10.1038/s41598-020-64895-4
PMCID: PMC7229016

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