Article
Gene conversion and duplication contribute to genetic variation in an outbreak of Mycobacterium tuberculosis.
Microbial genomics - 1 May 2025
Stritt Christoph, Reitsma Michelle, Marin Ana Maria Garcia, Goig Galo, Dötsch Anna, Borrell Sonia, Beisel Christian, Comas Iñaki, Brites Daniela, Gagneux Sebastien
Abstract excerpt
Repeats are the most diverse and dynamic but also the least well-understood component of microbial genomes. For all we know, repeat-associated mutations such as duplications, deletions, inversions and gene conversion might be as common as point mutations, but because of short-read myopia and methodological bias, they have received much less attention. Long-read DNA sequencing opens the perspective of resolving...
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