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Article

In vitro analysis of rates and spectra of mutations in a polymorphic region of the Rv0746 PE_PGRS gene of Mycobacterium tuberculosis.

Journal of bacteriology - 1 Mar 2007

Machowski Edith E, Barichievy Samantha, Springer Burkhard, Durbach Steven I, Mizrahi Valerie

Abstract excerpt

An assay modeled on a known polymorphism in the PE_PGRS9 gene of Mycobacterium tuberculosis was designed to assess the mutability of a sequence containing interspersed PGRS repeats. Application of the assay in Mycobacterium smegmatis revealed sequence plasticity: in addition to recapitulating the mutation on which it was based, other mutations likely mediated by replication slippage between PGRS repeats were...

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Identifiers

PMID: 17172340
DOI: 10.1128/JB.01647-06
PMCID: PMC1855714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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