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Gene conversion is a key driver of diversity hotspots in <i>M. tuberculosis</i> antigens and virulence-associated loci

2026-02-27

Abstract excerpt

Despite the long-held view of Mycobacterium tuberculosis ( Mtb ) as a genetically conserved pathogen, many genomic regions remain poorly resolved due to high sequence homology and repetitive content. Using complete genome assemblies generated from long-read sequencing of 151 globally representative clinical isolates, we comprehensively analyzed genome-wide patterns of genetic diversity and evolution across the...

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Literature Corpus work
7d4e03cc-9e15-592b-b13b-f9a74f38d64e
DOI
10.64898/2026.02.26.708061
Open publication

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Gene conversion is a key driver of diversity hotspots in <i>M. tuberculosis</i> antigens and virulence-associated lociDOI 10.64898/2026.02.26.708061
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