Article
Insights into the evolutionary history of tubercle bacilli as disclosed by genetic rearrangements within a PE_PGRS duplicated gene pair.
BMC evolutionary biology - 12 Dec 2006
Karboul Anis, Gey van Pittius Nicolaas C, Namouchi Amine, Vincent Véronique, Sola Christophe, Rastogi Nalin, Suffys Philip, Fabre Michel, Cataldi Angel, Huard Richard C, Kurepina Natalia, Kreiswirth Barry, Ho John L, Gutierrez M Cristina, Mardassi Helmi
Abstract excerpt
BACKGROUND: The highly homologous PE_PGRS (Proline-glutamic acid_polymorphic GC-rich repetitive sequence) genes are members of the PE multigene family which is found only in mycobacteria. PE genes are particularly abundant within the genomes of pathogenic mycobacteria where they seem to have expanded as a result of gene duplication events. PE_PGRS genes are characterized by their high GC content and extensive...
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