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Article

Mutational landscape of normal breast tissues adjacent to invasive breast cancer.

Cell reports. Medicine - 20 Jan 2026

Suwalska Aleksandra, Rozenblit Mariya, Harigopal Malini, Dai Jiawei, Liu Meng, Townsend Jeffrey P, Marczyk Michal, Pusztai Lajos

Abstract excerpt

Individuals with a history of breast cancer are at increased risk of developing a new breast cancer during their lifetime. Rare but high-impact somatic mutations in normal breast tissues may contribute to malignant transformation. We analyze mutations in cancer-relevant pathways across matched samples of peripheral blood, cancer-adjacent normal breast, and breast cancer from patients diagnosed before 50 years of...

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Identifiers

PMID: 41512875
DOI: 10.1016/j.xcrm.2025.102543
PMCID: PMC12866091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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