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The genomic, transcriptomic, and immunologic landscape of TEM8 (ANTXR1) in neuroendocrine neoplasms (NENs) including small-cell lung cancer (SCLC).

Cancer treatment and research communications - 1 Jan 2026

Kareff Samuel A, Krause Harris, Elliott Andrew, Samec Timothy, Lopes Gilberto, Hosein Peter J, Jani Chinmay T, Lou Emil, Soares Heloisa, Magistri Marco, Sumarriva Daniel, Oberley Matthew, Chauhan Aman

Abstract excerpt

PURPOSE: The TEM8 receptor (coded by ANTXR1) plays several roles in oncogenesis and novel oncolytic therapies, such as the SVV-01 virus, uniquely bind this protein in neuroendocrine tumor (NET) histologies, such as small-cell lung cancer (SCLC). Emerging pre-clinical data suggest that TEM8-targeting therapies may convert immunologically "cold" tumor microenvironments (TME) into "hot" milieu with greater responses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42061011
DOI: 10.1016/j.ctarc.2026.101190

Genes

ANTXR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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