Lung neuroendocrine tumours: deep sequencing of the four World Health Organization histotypes reveals chromatin-remodelling genes as major players and a prognostic role for TERT, RB1, MEN1 and KMT2D.

doi:10.1002/path.4853

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Article

Lung neuroendocrine tumours: deep sequencing of the four World Health Organization histotypes reveals chromatin-remodelling genes as major players and a prognostic role for TERT, RB1, MEN1 and KMT2D.

The Journal of pathology - 1 Mar 2017

Simbolo Michele, Mafficini Andrea, Sikora Katarzyna O, Fassan Matteo, Barbi Stefano, Corbo Vincenzo, Mastracci Luca, Rusev Borislav, Grillo Federica, Vicentini Caterina, Ferrara Roberto, Pilotto Sara, Davini Federico, Pelosi Giuseppe, Lawlor Rita T, Chilosi Marco, Tortora Giampaolo, Bria Emilio, Fontanini Gabriella, Volante Marco, Scarpa Aldo

Abstract excerpt

Next-generation sequencing (NGS) was applied to 148 lung neuroendocrine tumours (LNETs) comprising the four World Health Organization classification categories: 53 typical carcinoid (TCs), 35 atypical carcinoid (ACs), 27 large-cell neuroendocrine carcinomas, and 33 small-cell lung carcinomas. A discovery screen was conducted on 46 samples by the use of whole-exome sequencing and high-coverage targeted sequencing...

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Identifiers

PMID: 27873319
DOI: 10.1002/path.4853
PMCID: PMC5324596

Genes

MEN1
TERT
MYCL
POLQ
RICTOR
SDHA
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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