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Article

Integrative multi-omics profiling deciphers tumor microenvironment heterogeneity and immunotherapy vulnerabilities in lung neuroendocrine carcinomas.

Journal of advanced research - 1 Mar 2026

Zhang Zicheng, Zhai Modi, Bao Siqi, Sun Xujie, Chen Ruanqi, Wang Bingning, Yang Fan, Yang Lin, Zhou Meng

Abstract excerpt

INTRODUCTION: Lung neuroendocrine carcinomas (Lu-NECs) are rare, highly aggressive lung tumors with poor prognosis and limited therapeutic options. Understanding the tumor immune microenvironment (TIME) is crucial towards personalized therapeutic strategies. OBJECTIVES: This study aims to systematically characterize the heterogeneity and complexity of the TIME in Lu-NECs by integrating proteomic, transcriptomic,...

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Biomarkers, Tumor
Carcinoma, Neuroendocrine
Genomics
Immunotherapy
Multiomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Microenvironment

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PMID: 40513660
DOI: 10.1016/j.jare.2025.06.017
PMCID: PMC12957838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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