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Article

Molecular profiling METex14+ non-small cell lung cancer (NSCLC): Impact of histology.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2024

Marks Jennifer A, Gandhi Nishant, Halmos Balazs, Marmarelis Melina E, Yeon Kim So, Bazhenova Lyudmila, Ramalingam Suresh S, Xiu Joanne, Walker Phillip, Oberley Matthew J, Ma Patrick C, Liu Stephen V

Abstract excerpt

OBJECTIVES: MET exon 14 skipping alterations (METex14+) represent a heterogeneous subgroup of non-small cell lung cancer (NSCLC) with distinct biological and genomic features. We characterized this heterogeneity in a large cohort, integrating genomic and transcriptomic profiling with clinical outcomes, to elucidate the histologic and molecular traits and survival patterns of METex14+ NSCLC. MATERIALS AND METHODS:...

Topics

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Biomarkers, Tumor
Carcinoma, Non-Small-Cell Lung
Exome Sequencing
Exons
Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

High-Throughput Nucleotide Sequencing

Proto-Oncogene Proteins c-met

Source

Identifiers

PMID: 39241297
DOI: 10.1016/j.lungcan.2024.107935

Genes

MET
BRCA2
CDK4
HMGA2
KEAP1
MDM2
POT1
STK11
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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