Metabolic adaptation to IMMT deficiency through the ATF6-PPARγ axis is contingent on TP53 mutation status in breast cancer.

Abstract excerpt

Mitochondrial dysfunction and the corresponding metabolic reprogramming have been established as critical drivers of tumor progression; nevertheless, the specific molecular mechanisms have not yet been fully elucidated. In this study, we reveal that ablation of inner mitochondrial membrane protein (IMMT), a key architectural component of mitochondrial cristae, induces concurrent mitochondrial and endoplasmic...

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