Mitohormesis Primes Tumor Invasion and Metastasis

Abstract excerpt

Moderate mitochondrial stress can lead to persistent activation of cytoprotective mechanisms – a phenomenon termed mitohormesis. Here, we show that mitohormesis primes a subpopulation of cancer cells to basally upregulate mitochondrial stress responses, such as the mitochondrial unfolded protein response (UPR mt ) providing an adaptive metastatic advantage. In this subpopulation, UPR mt activation persists in the...

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