Article
Association of mprF mutations with cross-resistance to daptomycin and vancomycin in methicillin-resistant Staphylococcus aureus (MRSA).
Scientific reports - 30 Sept 2020
Thitiananpakorn Kanate, Aiba Yoshifumi, Tan Xin-Ee, Watanabe Shinya, Kiga Kotaro, Sato'o Yusuke, Boonsiri Tanit, Li Feng-Yu, Sasahara Teppei, Taki Yusuke, Azam Aa Haeruman, Zhang Yuancheng, Cui Longzhu
Abstract excerpt
We first reported a phenomenon of cross-resistance to vancomycin (VCM) and daptomycin (DAP) in methicillin-resistant Staphylococcus aureus (MRSA) in 2006, but mechanisms underlying the cross-resistance remain incompletely understood. Here, we present a follow-up study aimed to investigate genetic determinants associated with the cross-resistance. Using 12 sets of paired DAP susceptible (DAPS) and DAP...
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