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Article

Patient stratification by genetic risk in Alzheimer's disease is only effective in the presence of phenotypic heterogeneity.

PloS one - 1 Jan 2025

Euesden Jack, Ali Muhammad, Robins Chloe, Surendran Praveen, Gormley Padhraig, Pulford David, Cruchaga Carlos

Abstract excerpt

Case-only designs in longitudinal cohorts are a valuable resource for identifying disease-relevant genes, pathways, and novel targets influencing disease progression. This is particularly relevant in Alzheimer's disease (AD), where longitudinal cohorts measure disease "progression," defined by rate of cognitive decline. Few of the identified drug targets for AD have been clinically tractable, and phenotypic...

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Source

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Identifiers

PMID: 39787209
DOI: 10.1371/journal.pone.0310977
PMCID: PMC11717250

Genes

APOE

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