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Article

Whole-Exome Sequencing Identifies Frequent AHNAK2 Mutations With Prognostic Significance in Undifferentiated Primary Liver Carcinoma.

The American journal of surgical pathology - 1 Jul 2026

Zhu Ziqi, Tao Qing, Chen Liangyin, Zhu Hanwen, Li Nanjing, Wu Zhenru, Lu Changli, Shi Yujun

Abstract excerpt

Undifferentiated primary liver carcinoma (UPLC) is an exceedingly rare hepatic malignancy lacking hepatocytic or cholangiocytic differentiation, and its clinicopathologic and molecular characteristics remain poorly defined. We retrospectively analyzed 25 UPLC cases from a single Chinese institution over an 8-year period and performed whole-exome sequencing (WES) to delineate the genomic landscape, combined with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42030113
DOI: 10.1097/PAS.0000000000002554

Genes

AHNAK2
CD4
CD68
TERT
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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