Article

Genomic and transcriptomic somatic alterations of hepatocellular carcinoma in non-cirrhotic livers

2021-12-16

Abstract excerpt

<h4>Background</h4> Liver cancer is the second leading cause of cancer-related deaths worldwide. Hepatocellular carcinoma (HCC) risk factors include chronic hepatitis, cirrhosis, and alcohol abuse, whereby tumorigenesis is induced through inflammation and subsequent fibrotic response. However, a subset of HCC arises in non-cirrhotic livers. We characterized the genomic and transcriptomic landscape of non-cirrhoti...

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Literature Corpus work: 949b2e33-6d75-56e4-b6e1-424438ea3aee
DOI: 10.1101/2021.12.14.472689

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