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HLA Evolutionary Divergence and Paediatric Disease Risk: Unveiling Genetic Associations.

HLA - 1 Apr 2026

Madalese Donato, Auriemma Laura, Esposito Martina, Toriello Mario, Nappo Stefania, Lama Stefania, Topo Francesco, Gallo Lucia, Castellano Giovanni, Martino Natasha, Colucci Rosa, Crocchiolo Roberto, Tambaro Francesco Paolo, Penta de Vera d'Aragona Roberta

Abstract excerpt

The HLA system plays a crucial role in immune recognition, with genetic variability influencing disease susceptibility. This study examines the association between HLA evolutionary divergence (HED) scores and paediatric haematological malignancies, aiming to determine whether locus-specific HED profiles correlate with disease risk. A cohort of 89 paediatric patients (age ≤ 20) with high-resolution HLA typing (A,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42028798
DOI: 10.1111/tan.70721

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