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Article

Differences in meiotic recombination rates in childhood acute lymphoblastic leukemia at an MHC class II hotspot close to disease associated haplotypes.

PloS one - 1 Jan 2014

Thompson Pamela, Urayama Kevin, Zheng Jie, Yang Peng, Ford Matt, Buffler Patricia, Chokkalingam Anand, Lightfoot Tracy, Taylor Malcolm

Abstract excerpt

Childhood Acute Lymphoblastic Leukemia (ALL) is a malignant lymphoid disease of which B-cell precursor- (BCP) and T-cell- (T) ALL are subtypes. The role of alleles encoded by major histocompatibility loci (MHC) have been examined in a number of previous studies and results indicating weak, multi-allele associations between the HLA-DPB1 locus and BCP-ALL suggested a role for immunosusceptibility and possibly...

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Identifiers

PMID: 24959916
DOI: 10.1371/journal.pone.0100480
PMCID: PMC4069019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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