Polygenic risk score as a determinant of risk of non-melanoma skin cancer in a European-descent renal transplant cohort.

doi:10.1111/ajt.15057

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Article

Polygenic risk score as a determinant of risk of non-melanoma skin cancer in a European-descent renal transplant cohort.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Mar 2019

Stapleton Caragh P, Birdwell Kelly A, McKnight Amy Jayne, Maxwell Alexander P, Mark Patrick B, Sanders M Lee, Chapman Fiona A, van Setten Jessica, Phelan Paul J, Kennedy Claire, Jardine Alan, Traynor Jamie P, Keating Brendan, Conlon Peter J, Cavalleri Gianpiero L

Abstract excerpt

Renal transplant recipients have an increased risk of non-melanoma skin cancer (NMSC) compared to in the general population. Here, we show polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of NMSC in a general, nontransplant setting, can predict risk of, and time to posttransplant skin cancer. Genetic variants, reaching predefined P-value thresholds were chosen from published...

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Identifiers

PMID: 30085400
DOI: 10.1111/ajt.15057
PMCID: PMC6367067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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