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Article

A role for the Smc3 hinge domain in the maintenance of sister chromatid cohesion.

Molecular biology of the cell - 1 Feb 2018

Robison Brett, Guacci Vincent, Koshland Douglas

Abstract excerpt

Cohesin is a conserved protein complex required for sister chromatid cohesion, chromosome condensation, DNA damage repair, and regulation of transcription. Although cohesin functions to tether DNA duplexes, the contribution of its individual domains to this activity remains poorly understood. We interrogated the Smc3p subunit of cohesin by random insertion mutagenesis. Analysis of a mutant in the Smc3p hinge...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29187575
DOI: 10.1091/mbc.E17-08-0511
PMCID: PMC5996953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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