Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-Wide Association Study of Chronic Venous Insufficiency and Lymphedema in the Million Veteran Program.

Circulation. Genomic and precision medicine - 1 Jun 2026

Peloso Gina M, Adhikari Nimish, Young Melissa M, Cho Kelly, Kinlay Scott

Abstract excerpt

BACKGROUND: Lymphedema is a chronic condition characterized by the accumulation of fluid due to impaired lymphatic drainage, frequently occurring secondary to chronic venous insufficiency (CVI), malignancy, or obesity. Despite known environmental and clinical risk factors, the genetic contributors to lymphedema and CVI have been understudied. METHODS: We conducted a multipopulation genome-wide association study...

Topics

Join the communities discussing this publication.

Aged
Chronic Disease
NDP gene
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 42017216
DOI: 10.1161/CIRCGEN.125.005442

Genes

CASZ1
NDP
SLC12A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-Wide Association Study of Chronic Venous Insufficiency and Lymphedema in the Million Veteran Program.PMID 42017216Read ↗

Genome-wide association analysis and replication in 810,625 individuals with varicose veinsSemantic proximity Read ↗

Single-cell RNA-seq of the stromal vascular fraction of adipose tissue reveals lineage-specific changes in cancer-related lymphedemaSemantic proximity Read ↗

Exome sequencing identifies novel genetic variants associated with varicose veins.Semantic proximity Read ↗

Varicose veins of lower extremities: insights from the first large-scale genetic studySemantic proximity Read ↗

Genome-wide association studies in chronic venous disease: A systematic review.Semantic proximity Read ↗

Integrative analysis prioritizes the relevant genes and risk factors for chronic venous disease.Semantic proximity Read ↗

Multi-ancestry Genome-wide Association Study of Varicose Veins Reveals Polygenic Architecture, Genetic Overlap with Arterial and Venous Disease, and Novel Therapeutic OpportunitiesSemantic proximity Read ↗

Genome-wide association analysis and replication in 810,625 individuals identifies novel therapeutic targets for varicose veinsSemantic proximity Read ↗

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.Semantic proximity Read ↗

Varicose veins of lower extremities: Insights from the first large-scale genetic studySemantic proximity Read ↗

Genome-wide association study of a lipedema phenotype among women in the UK Biobank identifies multiple genetic risk factors.Semantic proximity Read ↗

Current Mechanistic Understandings of Lymphedema and Lipedema: Tales of Fluid, Fat, and FibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.