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Article

Exome sequencing identifies novel genetic variants associated with varicose veins.

PLoS genetics - 1 Jul 2024

Zhang Dan-Dan, He Xiao-Yu, Yang Liu, Wu Bang-Sheng, Fu Yan, Liu Wei-Shi, Guo Yu, Fei Chen-Jie, Kang Ju-Jiao, Feng Jian-Feng, Cheng Wei, Tan Lan, Yu Jin-Tai

Abstract excerpt

BACKGROUND: Varicose veins (VV) are one of the common human diseases, but the role of genetics in its development is not fully understood. METHODS: We conducted an exome-wide association study of VV using whole-exome sequencing data from the UK Biobank, and focused on common and rare variants using single-variant association analysis and gene-level collapsing analysis. FINDINGS: A total of 13,823,269 autosomal...

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Identifiers

PMID: 38980841
DOI: 10.1371/journal.pgen.1011339
PMCID: PMC11233024

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