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Article

Genome-wide association study of a lipedema phenotype among women in the UK Biobank identifies multiple genetic risk factors.

European journal of human genetics : EJHG - 1 Mar 2023

Klimentidis Yann C, Chen Zhao, Gonzalez-Garay Manuel L, Grigoriadis Dionysios, Sackey Ege, Pittman Alan, Ostergaard Pia, Herbst Karen L

Abstract excerpt

Lipedema is a common disorder characterized by excessive deposition of subcutaneous adipose tissue (SAT) in the legs, hips, and buttocks, mainly occurring in adult women. Although it appears to be heritable, no specific genes have yet been identified. To identify potential genetic risk factors for lipedema, we used bioelectrical impedance analysis and anthropometric data from the UK Biobank to identify women with...

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Biological Specimen Banks
Genome-Wide Association Study
Lymphatic System and Diseases
Phenotype
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Skin and Cellular Biology Research

Systemic Sclerosis and Related Diseases

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PMID: 36385154
DOI: 10.1038/s41431-022-01231-6
PMCID: PMC9995497

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