Article
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
Science (New York, N.Y.) - 19 Jul 2024
Verma Anurag, Huffman Jennifer E, Rodriguez Alex, Conery Mitchell, Liu Molei, Ho Yuk-Lam, Kim Youngdae, Heise David A, Guare Lindsay, Panickan Vidul Ayakulangara, Garcon Helene, Linares Franciel, Costa Lauren, Goethert Ian, Tipton Ryan, Honerlaw Jacqueline, Davies Laura, Whitbourne Stacey, Cohen Jeremy, Posner Daniel C, Sangar Rahul, Murray Michael, Wang Xuan, Dochtermann Daniel R, Devineni Poornima, Shi Yunling, Nandi Tarak Nath, Assimes Themistocles L, Brunette Charles A, Carroll Robert J, Clifford Royce, Duvall Scott, Gelernter Joel, Hung Adriana, Iyengar Sudha K, Joseph Jacob, Kember Rachel, Kranzler Henry, Kripke Colleen M, Levey Daniel, Luoh Shiuh-Wen, Merritt Victoria C, Overstreet Cassie, Deak Joseph D, Grant Struan F A, Polimanti Renato, Roussos Panos, Shakt Gabrielle, Sun Yan V, Tsao Noah, Venkatesh Sanan, Voloudakis Georgios, Justice Amy, Begoli Edmon, Ramoni Rachel, Tourassi Georgia, Pyarajan Saiju, Tsao Philip, O'Donnell Christopher J, Muralidhar Sumitra, Moser Jennifer, Casas Juan P, Bick Alexander G, Zhou Wei, Cai Tianxi, Voight Benjamin F, Cho Kelly, Gaziano J Michael, Madduri Ravi K, Damrauer Scott, Liao Katherine P
Abstract excerpt
One of the justifiable criticisms of human genetic studies is the underrepresentation of participants from diverse populations. Lack of inclusion must be addressed at-scale to identify causal disease factors and understand the genetic causes of health disparities. We present genome-wide associations for 2068 traits from 635,969 participants in the Department of Veterans Affairs Million Veteran Program, a...
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