Article

Single-cell RNA-seq of the stromal vascular fraction of adipose tissue reveals lineage-specific changes in cancer-related lymphedema

2020-09-28

Abstract excerpt

Lymphedema is a chronic tissue edema that frequently occurs following lymph node resection for cancer treatment, and is characterized by progressive swelling, chronic inflammation, excessive fibrosis and adipose deposition in the affected limbs. We still lack targeted medical therapies for this disease due to the incomplete understanding of the mechanism underlying the pathogenesis. Here, we performed single-cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52c8b373-c2c8-5468-a9f2-8296a44a1f1e
DOI: 10.1101/2020.09.27.315911

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell RNA-seq of the stromal vascular fraction of adipose tissue reveals lineage-specific changes in cancer-related lymphedemaDOI 10.1101/2020.09.27.315911Read

Multi-level analysis of adipose tissue reveals the relevance of perivascular subpopulations and an increased endothelial permeability in early-stage lipedemaSemantic proximity Read

Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell populationSemantic proximity Read

Identification of novel hub genes and pathways predictive of fibrosis progression in cancer-related lymphedema through integrated multi-omicsSemantic proximity Read

Multi-omics characterization of lymphedema-induced adipose tissue from breast cancer patientsSemantic proximity Read

A distinct M2 macrophage infiltrate and transcriptomic profile decisively influence adipocyte differentiation in lipedemaSemantic proximity Read

Current Mechanistic Understandings of Lymphedema and Lipedema: Tales of Fluid, Fat, and FibrosisSemantic proximity Read

Pathogenesis of Lipedema—A Regenerative ImbalanceSemantic proximity Read

A Perforator-Based Adipocutaneous Skin Paddle derived from Free Muscle Flap Reconstruction: The First in-Human Model of Secondary LymphedemaSemantic proximity Read

Single-cell RNA sequencing reveals distinct immunology profiles in human keloidSemantic proximity Read

Abnormal lymphatic S1P signaling aggravates lymphatic dysfunction and tissue inflammationSemantic proximity Read

Histopathologic Features of Lymphedema: A Molecular Review.Semantic proximity Read

The shifting of dominating roles between structural cells and immune cells are key regulators of human adipose tissues agingSemantic proximity Read