Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Varicose veins of lower extremities: Insights from the first large-scale genetic study

18 Apr 2019

Abstract excerpt

Varicose veins of lower extremities (VVs) are a common multifactorial vascular disease. Genetic factors underlying VVs development remain largely unknown. Here we report the first large-scale study of VVs performed on a freely available genetic data of 408,455 European-ancestry individuals. We identified the 12 reliably associated loci that explain 13% of the SNP-based heritability, and prioritized the most...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Effects of Exercise
Share to Venous Thromboembolism Diagnosis and Management

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 30998689
DOI: 10.1371/journal.pgen.1008110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Varicose veins of lower extremities: Insights from the first large-scale genetic studyPMID 30998689Read ↗

Varicose veins of lower extremities: insights from the first large-scale genetic studySemantic proximity Read ↗

Genome-wide association analysis and replication in 810,625 individuals identifies novel therapeutic targets for varicose veinsSemantic proximity Read ↗

Exome sequencing identifies novel genetic variants associated with varicose veins.Semantic proximity Read ↗

Genome-wide association analysis and replication in 810,625 individuals with varicose veinsSemantic proximity Read ↗

Clinical and Genetic Determinants of Varicose VeinsSemantic proximity Read ↗

Polymorphisms of genes involved in inflammation and blood vessel development influence the risk of varicose veins.Semantic proximity Read ↗

Genome-wide association studies in chronic venous disease: A systematic review.Semantic proximity Read ↗

Pathophysiology and Genetic Associations of Varicose Veins: A Narrative Review.Semantic proximity Read ↗

Multi-ancestry Genome-wide Association Study of Varicose Veins Reveals Polygenic Architecture, Genetic Overlap with Arterial and Venous Disease, and Novel Therapeutic OpportunitiesSemantic proximity Read ↗

Genome-wide association study of varicose veins identifies a protective missense variant in GJD3 enriched in the Finnish populationSemantic proximity Read ↗

Integrative analysis prioritizes the relevant genes and risk factors for chronic venous disease.Semantic proximity Read ↗

Novel susceptibility genes for varicose veins revealed by a cross-tissue transcriptome-wide association study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.