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Article

The lipidomes of C. elegans with mutations in asm-3/acid sphingomyelinase and hyl-2/ceramide synthase show distinct lipid profiles during aging.

Aging - 13 Feb 2023

Staab Trisha A, McIntyre Grace, Wang Lu, Radeny Joycelyn, Bettcher Lisa, Guillen Melissa, Peck Margaret P, Kalil Azia P, Bromley Samantha P, Raftery Daniel, Chan Jason P

Abstract excerpt

Lipid metabolism affects cell and physiological functions that mediate animal healthspan and lifespan. Lipidomics approaches in model organisms have allowed us to better understand changes in lipid composition related to age and lifespan. Here, using the model C. elegans, we examine the lipidomes of mutants lacking enzymes critical for sphingolipid metabolism; specifically, we examine acid sphingomyelinase...

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Identifiers

PMID: 36787434
DOI: 10.18632/aging.204515
PMCID: PMC9970312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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