Distinct mechanisms decommission redundant enhancers to facilitate phenotypic evolution.

Abstract excerpt

The evolutionary loss of morphological traits is often driven by changes in gene regulation. Many developmental genes are controlled by multiple redundant enhancers, raising the question of how robust regulatory systems can be dismantled to permit phenotypic transitions. Here, we show that the loss of larval trichomes in Drosophila sechellia resulted from the independent inactivation of four embryonic enhancers...

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