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Article

Variation and constraint in Hox gene evolution.

Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2013

Heffer Alison, Xiang Jie, Pick Leslie

Abstract excerpt

Despite enormous body plan variation, genes regulating embryonic development are highly conserved. Here, we probe the mechanisms that predispose ancient regulatory genes to reutilization and diversification rather than evolutionary loss. The Hox gene fushi tarazu (ftz) arose as a homeotic gene but functions as a pair-rule segmentation gene in Drosophila. ftz shows extensive variation in expression and protein...

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Identifiers

PMID: 23341600
DOI: 10.1073/pnas.1210847110
PMCID: PMC3568319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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