Article
Variation and constraint in Hox gene evolution.
Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2013
Heffer Alison, Xiang Jie, Pick Leslie
Abstract excerpt
Despite enormous body plan variation, genes regulating embryonic development are highly conserved. Here, we probe the mechanisms that predispose ancient regulatory genes to reutilization and diversification rather than evolutionary loss. The Hox gene fushi tarazu (ftz) arose as a homeotic gene but functions as a pair-rule segmentation gene in Drosophila. ftz shows extensive variation in expression and protein...
Topics
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Antennapedia Homeodomain Protein
- Artemia
- Arthropods
- Central Nervous System
- Coleoptera
- Drosophila Proteins
- Drosophila melanogaster
- Evolution, Molecular