Article
Stepwise modification of a modular enhancer underlies adaptation in a Drosophila population.
Science (New York, N.Y.) - 18 Dec 2009
Rebeiz Mark, Pool John E, Kassner Victoria A, Aquadro Charles F, Carroll Sean B
Abstract excerpt
The evolution of cis regulatory elements (enhancers) of developmentally regulated genes plays a large role in the evolution of animal morphology. However, the mutational path of enhancer evolution--the number, origin, effect, and order of mutations that alter enhancer function--has not been elucidated. Here, we localized a suite of substitutions in a modular enhancer of the ebony locus responsible for adaptive...
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