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Article

Gene regulatory network architecture in different developmental contexts influences the genetic basis of morphological evolution.

PLoS genetics - 1 May 2018

Kittelmann Sebastian, Buffry Alexandra D, Franke Franziska A, Almudi Isabel, Yoth Marianne, Sabaris Gonzalo, Couso Juan Pablo, Nunes Maria D S, Frankel Nicolás, Gómez-Skarmeta José Luis, Pueyo-Marques Jose, Arif Saad, McGregor Alistair P

Abstract excerpt

Convergent phenotypic evolution is often caused by recurrent changes at particular nodes in the underlying gene regulatory networks (GRNs). The genes at such evolutionary 'hotspots' are thought to maximally affect the phenotype with minimal pleiotropic consequences. This has led to the suggestion that if a GRN is understood in sufficient detail, the path of evolution may be predictable. The repeated evolutionary...

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Identifiers

PMID: 29723190
DOI: 10.1371/journal.pgen.1007375
PMCID: PMC5953500

Genes

GRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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