Article
Evolved Repression Overcomes Enhancer Robustness.
Developmental cell - 5 Dec 2016
Preger-Ben Noon Ella, Davis Fred P, Stern David L
Abstract excerpt
Biological systems display extraordinary robustness. Robustness of transcriptional enhancers results mainly from clusters of binding sites for the same transcription factor, and it is not clear how robust enhancers can evolve loss of expression through point mutations. Here, we report the high-resolution functional dissection of a robust enhancer of the shavenbaby gene that has contributed to morphological...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.