Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Morphological evolution caused by many subtle-effect substitutions in regulatory DNA.

Nature - 29 Jun 2011

Frankel Nicolás, Erezyilmaz Deniz F, McGregor Alistair P, Wang Shu, Payre François, Stern David L

Abstract excerpt

Morphology evolves often through changes in developmental genes, but the causal mutations, and their effects, remain largely unknown. The evolution of naked cuticle on larvae of Drosophila sechellia resulted from changes in five transcriptional enhancers of shavenbaby (svb), a transcript of the ovo locus that encodes a transcription factor that governs morphogenesis of microtrichiae, hereafter called 'trichomes'....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to Drosophila melanogaster
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to Enhancer Elements, Genetic

Share to Gene Expression Regulation, Developmental

Share to Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 21720363
DOI: 10.1038/nature10200
PMCID: PMC3170772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Morphological evolution caused by many subtle-effect substitutions in regulatory DNA.PMID 21720363Read ↗

A complex gene regulatory architecture underlies the development and evolution of cuticle morphology in Drosophila.Semantic proximity Read ↗

Morphological evolution through multiple cis-regulatory mutations at a single gene.Semantic proximity Read ↗

The developmental genetics of microevolution.Semantic proximity Read ↗

Distinct mechanisms decommission redundant enhancers to facilitate phenotypic evolution.Semantic proximity Read ↗

Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution.Semantic proximity Read ↗

Evolutionary genetics: how flies get naked.Semantic proximity Read ↗

Cis-regulatory variation in the shavenbaby gene underlies intraspecific phenotypic variation, mirroring interspecific divergence in the same trait.Semantic proximity Read ↗

Phenotypic robustness conferred by apparently redundant transcriptional enhancers.Semantic proximity Read ↗

Gene regulatory network architecture in different developmental contexts influences the genetic basis of morphological evolution.Semantic proximity Read ↗

Gene regulatory network co-option is sufficient to induce a morphological novelty in <i>Drosophila</i>Semantic proximity Read ↗

Stepwise modification of a modular enhancer underlies adaptation in a Drosophila population.Semantic proximity Read ↗

Functional genetic elements of a butterfly mimicry supergene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.