Article
Natural Modulators of the TP53 Pathway: Potential Herbal and Plant-Derived Agents for Cancer Therapy.
Phytotherapy research : PTR - 1 Jun 2026
Nandi Sudeshna, Naskar Arghya, Khatua Somanjana, Acharya Krishnendu, Büsselberg Dietrich, Herrera-Bravo Jesús, Arancibia-Diaz Alejandra, Setzer William N, Rotariu Lia Sanda, Dragunescu Anca Aneta, Butnariu Monica, Sharifi-Rad Javad
Abstract excerpt
The transcription factor p53, often called the "guardian of the genome," is critical for preserving genomic integrity. Mutations in the TP53 gene are found in approximately half of all human malignancies, including breast, colon, lung, liver, prostate, bladder, and skin cancers. p53 is activated by a wide range of cellular stress signals and orchestrates specific cellular responses based on the context and nature...
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