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Article

Synthetic coevolution reveals adaptive mutational trajectories of neutralizing antibodies and SARS-CoV-2.

Cell systems - 17 Sept 2025

Ehling Roy A, Minot Mason, Overath Max D, Sheward Daniel J, Han Jiami, Gao Beichen, Taft Joseph M, Pertseva Margarita, Weber Cédric R, Frei Lester, Bikias Thomas, Murrell Ben, Reddy Sai T

Abstract excerpt

The COVID-19 pandemic showcased a coevolutionary race between the human immune system and SARS-CoV-2, during which the immune system generated neutralizing antibodies targeting the SARS-CoV-2 spike protein's receptor-binding domain (RBD), crucial for host cell invasion, while the virus evolved to evade antibody recognition. Here, we establish a synthetic coevolution system combining high-throughput screening of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40967184
DOI: 10.1016/j.cels.2025.101391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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