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Article

DPP6 Loss Causes Age-Dependent Sleep Dysregulation and Depression-like Phenotypes Linked to Neurodegeneration.

International journal of molecular sciences - 2 Apr 2026

Lin Lin, Pratt Ashley E, Hoffman Dax A

Abstract excerpt

Sleep disturbances are early hallmarks of Alzheimer's disease (AD) and other dementias, yet the molecular mechanisms remain poorly understood. We previously showed that dipeptidyl aminopeptidase-like protein 6-knockout (DPP6-KO) mice exhibit accelerated neurodegeneration with synaptic loss, neuronal death, and circadian dysfunction resembling AD pathology. Here, we investigate whether DPP6 deficiency directly...

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Source

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Identifiers

PMID: 41977406
DOI: 10.3390/ijms27073224
PMCID: PMC13072965

Genes

DPP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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