Article
Altered Motor Performance, Sleep EEG, and Parkinson's Disease Pathology Induced by Chronic Sleep Deprivation in Lrrk2G2019S Mice.
Neuroscience bulletin - 1 Oct 2022
Liu Xinyao, Yu Hang, Wang Yuanyuan, Li Song, Cheng Cheng, Al-Nusaif Murad, Le Weidong
Abstract excerpt
Parkinson's disease (PD) is a multifaceted disease in which environmental variables combined with genetic predisposition cause dopaminergic (DAergic) neuron loss in the substantia nigra pars compacta. The mutation of leucine-rich repeat kinase 2 (Lrrk2) is the most common autosomal dominant mutation in PD, and it has also been reported in sporadic cases. A growing body of research suggests that circadian rhythm...
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