Article

Diphenhydramine Disrupts Sleep Architecture in 5XFAD Alzheimer’s Disease Model and Wild-Type Mice

2026-07-27

Abstract excerpt

Sleep disruption is common in Alzheimer’s disease (AD). Diphenhydramine (DPH), a first-generation antihistamine with anticholinergic properties, is widely used as an over-the-counter sleep aid. We tested whether chronic DPH treatment alters sleep architecture in 5XFAD and wild-type mice. Female 5XFAD (n=16) and wild-type (WT) littermates (n=14) were implanted with wireless telemetry recording devices to measure el...

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Literature Corpus work: 3ba28cc9-d710-5940-80fd-96b44f5232b4
DOI: 10.64898/2026.07.22.739929

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