Article
Exploring biologically relevant pathways in frailty.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Sept 2011
Ho Yen-Yi, Matteini Amy M, Beamer Brock, Fried Linda, Xue Qian-li, Arking Dan E, Chakravarti Aravinda, Fallin M Daniele, Walston Jeremy
Abstract excerpt
BACKGROUND: Frailty is a late-life syndrome of vulnerability to adverse health outcomes characterized by a phenotype that includes muscle weakness, fatigue, and inflammatory pathway activation. The identification of biologically relevant pathways that influence frailty is challenged by its biological complexity and the necessity in separating disease states from the syndrome of frailty. As with longevity...
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