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Article

Proinflammatory genotype is associated with the frailty phenotype in the English Longitudinal Study of Ageing.

Aging clinical and experimental research - 1 Jun 2016

Mekli Krisztina, Nazroo James Y, Marshall Alan D, Kumari Meena, Pendleton Neil

Abstract excerpt

BACKGROUND: Frailty is a state of increased vulnerability to poor resolution of homeostasis after a stressor event, which increases the risk of adverse outcomes including falls, disability and death. The underlying pathophysiological pathways of frailty are not known but the hypothalamic-pituitary-adrenal axis and heightened chronic systemic inflammation appear to be major contributors. METHODS: We used the...

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Identifiers

PMID: 26248682
DOI: 10.1007/s40520-015-0419-z
PMCID: PMC4877432

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TNF
PTPRJ

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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